Sheppard was born in Cleveland, Ohio, the youngest of three sons of Dr. Richard Allen Sheppard. He attended Cleveland Heights High School where he was an excellent student and was active in football, basketball, and track; he was class president for three years. Sheppard met his future wife, Marilyn Reese, while in high school. Although several small Ohio colleges offered him athletic scholarships, Sheppard chose to follow the lead of his father and older brothers and pursued a career in osteopathic medicine. He enrolled at Hanover College in Indiana to study prepositional courses, then took supplementary courses at Western Reserve University in Cleveland. Sheppard finished his medical education at the Los Angeles Osteopathic School of Physicians and Surgeons and was awarded the D.O. degree. He completed his internship and a residency in neurosurgery at Los Angeles County General Hospital. A few years after marrying Marilyn Reese on February 21, 1945, in Hollywood, California, Sheppard returned to Ohio and joined his father's growing medical practice at Bay View Hospital.
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